He went on to appear in several television series including Nightingales, Men of the World, Cutting It, The Knock, CI5: The New Professionals, Spooks, and Shameless. He also had many notable roles on stage in plays like Riddley Walker, Oedipus, Macbeth, Your Home In The West, and Peer Gynt. Most recently, it was announced that Threlfall has been cast as Noah in the BBC biblical drama, The Ark, which has started filming in Morocco. Threlfall has been married to Bosnian actress, Brana Bajic since 1995 and the couple have two children. They met in 1994 while working on The Count of Monte Cristo at the Royal Exchange Theatre in Manchester.