After a nearly four-year hiatus, Villarreal announced she was in the studio recording her 4th solo album. La Jefa was released June 23, 2009 with Caso Perdido as lead single. The album debuted at No. 1 on Billboard’s Regional Mexican Albums and overall at No. 4 on its Latin Albums chart. Caso Perdido, as a single, did not achieve the same success as prior single releases. Alicia Villarreal married her first husband, record producer Ezequiel Cuevas, in 1991 and they divorced in 1993. She married Arturo Carmona on December 16, 1998 and they had a daughter, Melenie Aidée Carmona Villarreal, on April 10, 1999. The couple divorced in 2001. On October 10, 2009 Alicia Villarreal’s brother José Víctor Villarreal Esparza, then 36 years old, was killed in a car accident in Monterrey, Nuevo León, Mexico.